The 2022 United States Senate election in Alaska will be held on November 8, 2022. Incumbent three-term Republican U.S. Senator Lisa Murkowski is running for reelection to a fourth term.

Following voter approval of Ballot Measure 2 during the 2020 elections in Alaska, this will be the first U.S. Senate election in Alaska held under a new election process. All candidates will run in a nonpartisan blanket top-four primary on August 16, 2022, from which the top four candidates will advance to the general election. Voters will then utilize ranked-choice voting during the general election.

On March 16, 2021, the Alaska Republican Party voted to censure Murkowski and announced that they would recruit a Republican challenger in the 2022 election cycle.[3][4] Due to Murkowski’s opposition to some of his initiatives and her vote for conviction following his second impeachment trial, former U.S. President Donald Trump pledged to campaign against Murkowski in 2022.

Murkowski was appointed to the Senate in 2002 by her father Frank Murkowski, who had just resigned from the seat himself after being elected Governor of Alaska. Defeated in the Republican primary in the 2010 election[7], she went on to win the general election as a write-in candidate, becoming one of only two U.S. senators in history to have done so.